VCP/p97 cooperates with YOD1, UBXD1 and PLAA to drive clearance of ruptured lysosomes by autophagy

Rupture of endosomes and lysosomes is a major cellular stress condition leading to cell death and degeneration. Here, we identified an essential role for the ubiquitin‐directed AAA‐ATPase, p97, in the clearance of damaged lysosomes by autophagy. Upon damage, p97 translocates to lysosomes and there c...

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Pubblicato in:EMBO J
Autori principali: Papadopoulos, Chrisovalantis, Kirchner, Philipp, Bug, Monika, Grum, Daniel, Koerver, Lisa, Schulze, Nina, Poehler, Robert, Dressler, Alina, Fengler, Sven, Arhzaouy, Khalid, Lux, Vanda, Ehrmann, Michael, Weihl, Conrad C, Meyer, Hemmo
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2016
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Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5242375/
https://ncbi.nlm.nih.gov/pubmed/27753622
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201695148
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