VCP/p97 cooperates with YOD1, UBXD1 and PLAA to drive clearance of ruptured lysosomes by autophagy

Rupture of endosomes and lysosomes is a major cellular stress condition leading to cell death and degeneration. Here, we identified an essential role for the ubiquitin‐directed AAA‐ATPase, p97, in the clearance of damaged lysosomes by autophagy. Upon damage, p97 translocates to lysosomes and there c...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:EMBO J
Egile Nagusiak: Papadopoulos, Chrisovalantis, Kirchner, Philipp, Bug, Monika, Grum, Daniel, Koerver, Lisa, Schulze, Nina, Poehler, Robert, Dressler, Alina, Fengler, Sven, Arhzaouy, Khalid, Lux, Vanda, Ehrmann, Michael, Weihl, Conrad C, Meyer, Hemmo
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: John Wiley and Sons Inc. 2016
Gaiak:
Articles
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5242375/
https://ncbi.nlm.nih.gov/pubmed/27753622
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201695148
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