VCP/p97 cooperates with YOD1, UBXD1 and PLAA to drive clearance of ruptured lysosomes by autophagy

Rupture of endosomes and lysosomes is a major cellular stress condition leading to cell death and degeneration. Here, we identified an essential role for the ubiquitin‐directed AAA‐ATPase, p97, in the clearance of damaged lysosomes by autophagy. Upon damage, p97 translocates to lysosomes and there c...

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Bibliographic Details
Published in:EMBO J
Main Authors: Papadopoulos, Chrisovalantis, Kirchner, Philipp, Bug, Monika, Grum, Daniel, Koerver, Lisa, Schulze, Nina, Poehler, Robert, Dressler, Alina, Fengler, Sven, Arhzaouy, Khalid, Lux, Vanda, Ehrmann, Michael, Weihl, Conrad C, Meyer, Hemmo
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5242375/
https://ncbi.nlm.nih.gov/pubmed/27753622
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201695148
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