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Antigen-independent memory CD8 T cells do not develop during chronic viral infection

Memory T cells can persist for extended periods in the absence of antigen, and long-term T cell immunity is often seen after acute infections. Paradoxically, there have been observations suggesting that T cell memory may be antigen-dependent during chronic infections. To elucidate the underlying mec...

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Bibliographic Details
Main Authors: Wherry, E. John, Barber, Daniel L., Kaech, Susan M., Blattman, Joseph N., Ahmed, Rafi
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2004
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC524220/
https://ncbi.nlm.nih.gov/pubmed/15505208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0407192101
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