Antigen-specific CD4 T-cell help rescues exhausted CD8 T cells during chronic viral infection

CD4 T cells play a critical role in regulating CD8 T-cell responses during chronic viral infection. Several studies in animal models and humans have shown that the absence of CD4 T-cell help results in severe dysfunction of virus-specific CD8 T cells. However, whether function can be restored in alr...

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Detalhes bibliográficos
Main Authors: Aubert, Rachael D., Kamphorst, Alice O., Sarkar, Surojit, Vezys, Vaiva, Ha, Sang-Jun, Barber, Daniel L., Ye, Lilin, Sharpe, Arlene H., Freeman, Gordon J., Ahmed, Rafi
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2011
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3248546/
https://ncbi.nlm.nih.gov/pubmed/22160724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1118450109
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