Inhibition of SGLT2 alleviates diabetic nephropathy by suppressing high glucose‐induced oxidative stress in type 1 diabetic mice

It is unclear whether the improvement in diabetic nephropathy by sodium glucose cotransporter 2 (SGLT2) inhibitors is caused by a direct effect on SGLT2 or by the improvement in hyperglycemia. Here, we investigated the effect of dapagliflozin on early‐stage diabetic nephropathy using a mouse model o...

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Bibliographische Detailangaben
Veröffentlicht in:Pharmacol Res Perspect
Hauptverfasser: Hatanaka, Takashi, Ogawa, Daisuke, Tachibana, Hiromi, Eguchi, Jun, Inoue, Tatsuyuki, Yamada, Hiroshi, Takei, Kohji, Makino, Hirofumi, Wada, Jun
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2016
Schlagworte:
Original Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5242174/
https://ncbi.nlm.nih.gov/pubmed/28116093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prp2.239
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