Pemt Deficiency Ameliorates Endoplasmic Reticulum Stress in Diabetic Nephropathy

Phosphatidylethanolamine N-methyltransferase (Pemt) catalyzes the methylation of phosphatidylethanolamine (PE) to phosphatidylcholine (PC) mainly in the liver. Under an obese state, the upregulation of Pemt induces endoplasmic reticulum (ER) stress by increasing the PC/PE ratio in the liver. We targ...

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Bibliographische Detailangaben
Hauptverfasser: Watanabe, Mayu, Nakatsuka, Atsuko, Murakami, Kazutoshi, Inoue, Kentaro, Terami, Takahiro, Higuchi, Chigusa, Katayama, Akihiro, Teshigawara, Sanae, Eguchi, Jun, Ogawa, Daisuke, Watanabe, Eijiro, Wada, Jun, Makino, Hirofumi
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2014
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3965443/
https://ncbi.nlm.nih.gov/pubmed/24667182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0092647
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