Pemt Deficiency Ameliorates Endoplasmic Reticulum Stress in Diabetic Nephropathy

Phosphatidylethanolamine N-methyltransferase (Pemt) catalyzes the methylation of phosphatidylethanolamine (PE) to phosphatidylcholine (PC) mainly in the liver. Under an obese state, the upregulation of Pemt induces endoplasmic reticulum (ER) stress by increasing the PC/PE ratio in the liver. We targ...

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Autori principali: Watanabe, Mayu, Nakatsuka, Atsuko, Murakami, Kazutoshi, Inoue, Kentaro, Terami, Takahiro, Higuchi, Chigusa, Katayama, Akihiro, Teshigawara, Sanae, Eguchi, Jun, Ogawa, Daisuke, Watanabe, Eijiro, Wada, Jun, Makino, Hirofumi
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2014
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3965443/
https://ncbi.nlm.nih.gov/pubmed/24667182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0092647
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