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Pemt Deficiency Ameliorates Endoplasmic Reticulum Stress in Diabetic Nephropathy

Phosphatidylethanolamine N-methyltransferase (Pemt) catalyzes the methylation of phosphatidylethanolamine (PE) to phosphatidylcholine (PC) mainly in the liver. Under an obese state, the upregulation of Pemt induces endoplasmic reticulum (ER) stress by increasing the PC/PE ratio in the liver. We targ...

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Detalhes bibliográficos
Main Authors: Watanabe, Mayu, Nakatsuka, Atsuko, Murakami, Kazutoshi, Inoue, Kentaro, Terami, Takahiro, Higuchi, Chigusa, Katayama, Akihiro, Teshigawara, Sanae, Eguchi, Jun, Ogawa, Daisuke, Watanabe, Eijiro, Wada, Jun, Makino, Hirofumi
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3965443/
https://ncbi.nlm.nih.gov/pubmed/24667182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0092647
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