A β-oxidation-resistant lipoxin A(4) analog treats hapten-induced colitis by attenuating inflammation and immune dysfunction

Lipoxins and aspirin-triggered 15-epi-lipoxins (ATL) are counter-regulatory eicosanoids with potent antiinflammatory actions. Oral efficacy and mechanism of action of ZK-192, a β-oxidation-resistant 3-oxa-ATL analog, were examined in trinitrobenzenesulphonate (TNBS)-induced colitis. When dosed orall...

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Detalhes bibliográficos
Main Authors: Fiorucci, Stefano, Wallace, John L., Mencarelli, Andrea, Distrutti, Eleonora, Rizzo, Giovanni, Farneti, Silvana, Morelli, Antonio, Tseng, Jih-Lie, Suramanyam, Babu, Guilford, William J., Parkinson, John F.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2004
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC524215/
https://ncbi.nlm.nih.gov/pubmed/15505205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0404722101
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