Evidence that 5-lipoxygenase and acetylated cyclooxygenase 2-derived eicosanoids regulate leukocyte–endothelial adherence in response to aspirin

1. Unlike other nonsteroidal anti-inflammatory drugs that inhibit formation of cyclooxygenase (COX)-dependent eicosanoids, acetylation of COX-2 by aspirin switches eicosanoid biosynthesis from prostaglandin E(2) (PGE(2)) to 15-epi-lipoxin A(4) (15-epi-LXA(4) or aspirin-triggered lipoxin, ATL). ATL f...

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Bibliografiske detaljer
Main Authors: Fiorucci, Stefano, Distrutti, Eleonora, Mencarelli, Andrea, Morelli, Antonio, Laufor, Stefan A, Cirino, Giuseppe, Wallace, John L
Format: Artigo
Sprog:Inglês
Udgivet: 2003
Fag:
Papers
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1573955/
https://ncbi.nlm.nih.gov/pubmed/12890715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0705356
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