Medium throughput bisulfite sequencing for accurate detection of 5-methylcytosine and 5-hydroxymethylcytosine

BACKGROUND: Epigenetic modifications of DNA, such as 5-methylcytosine and 5-hydroxymethycytosine, play important roles in development and disease. Here, we present a cost-effective and versatile methodology for the analysis of DNA methylation in targeted genomic regions, which comprises multiplexed,...

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Pubblicato in:BMC Genomics
Autori principali: Chen, Gary G., Gross, Jeffrey A., Lutz, Pierre-Eric, Vaillancourt, Kathryn, Maussion, Gilles, Bramoulle, Alexandre, Théroux, Jean-François, Gardini, Elena S., Ehlert, Ulrike, Bourret, Geneviève, Masurel, Aurélie, Lepage, Pierre, Mechawar, Naguib, Turecki, Gustavo, Ernst, Carl
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2017
Soggetti:
Methodology Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5242011/
https://ncbi.nlm.nih.gov/pubmed/28100169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12864-017-3489-9
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