Leucine-rich repeat kinase-1 regulates osteoclast function by modulating RAC1/Cdc42 Small GTPase phosphorylation and activation

Leucine-rich repeat kinase-1 (Lrrk1) consists of ankyrin repeats (ANK), leucine-rich repeats (LRR), a GTPase-like domain of Roc (ROC), a COR domain, a serine/threonine kinase domain (KD), and WD40 repeats (WD40). Previous studies have revealed that knockout (KO) of Lrrk1 in mice causes severe osteop...

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Published in:Am J Physiol Endocrinol Metab
Main Authors: Zeng, Canjun, Goodluck, Helen, Qin, Xuezhong, Liu, Bo, Mohan, Subburaman, Xing, Weirong
Format: Artigo
Language:Inglês
Published: American Physiological Society 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5241559/
https://ncbi.nlm.nih.gov/pubmed/27600824
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00189.2016
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