FUNCTIONAL SUBCLONE PROFILING FOR PREDICTION OF TREATMENT-INDUCED INTRA-TUMOR POPULATION SHIFTS AND DISCOVERY OF RATIONAL DRUG COMBINATIONS IN HUMAN GLIOBLASTOMA

PURPOSE: Investigation of clonal heterogeneity may be key to understanding mechanisms of therapeutic failure in human cancer. However, little is known on the consequences of therapeutic intervention on the clonal composition of solid tumors. EXPERIMENTAL DESIGN: Here, we used 33 single cell-derived...

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Detaylı Bibliyografya
Yayımlandı:Clin Cancer Res
Asıl Yazarlar: Reinartz, Roman, Wang, Shanshan, Kebir, Sied, Silver, Daniel J., Wieland, Anja, Zheng, Tong, Küpper, Marius, Rauschenbach, Laurèl, Fimmers, Rolf, Shepherd, Timothy M., Trageser, Daniel, Till, Andreas, Schäfer, Niklas, Glas, Martin, Hillmer, Axel M., Cichon, Sven, Smith, Amy A., Pietsch, Torsten, Liu, Ying, Reynolds, Brent A., Yachnis, Anthony, Pincus, David W., Simon, Matthias, Brüstle, Oliver, Steindler, Dennis A., Scheffler, Björn
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2016
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5241221/
https://ncbi.nlm.nih.gov/pubmed/27521447
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-15-2089
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