FUNCTIONAL SUBCLONE PROFILING FOR PREDICTION OF TREATMENT-INDUCED INTRA-TUMOR POPULATION SHIFTS AND DISCOVERY OF RATIONAL DRUG COMBINATIONS IN HUMAN GLIOBLASTOMA

PURPOSE: Investigation of clonal heterogeneity may be key to understanding mechanisms of therapeutic failure in human cancer. However, little is known on the consequences of therapeutic intervention on the clonal composition of solid tumors. EXPERIMENTAL DESIGN: Here, we used 33 single cell-derived...

وصف كامل

محفوظ في:
التفاصيل البيبلوغرافية
الحاوية / القاعدة:Clin Cancer Res
المؤلفون الرئيسيون: Reinartz, Roman, Wang, Shanshan, Kebir, Sied, Silver, Daniel J., Wieland, Anja, Zheng, Tong, Küpper, Marius, Rauschenbach, Laurèl, Fimmers, Rolf, Shepherd, Timothy M., Trageser, Daniel, Till, Andreas, Schäfer, Niklas, Glas, Martin, Hillmer, Axel M., Cichon, Sven, Smith, Amy A., Pietsch, Torsten, Liu, Ying, Reynolds, Brent A., Yachnis, Anthony, Pincus, David W., Simon, Matthias, Brüstle, Oliver, Steindler, Dennis A., Scheffler, Björn
التنسيق: Artigo
اللغة:Inglês
منشور في: 2016
الموضوعات:
Article
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC5241221/
https://ncbi.nlm.nih.gov/pubmed/27521447
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-15-2089
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