FUNCTIONAL SUBCLONE PROFILING FOR PREDICTION OF TREATMENT-INDUCED INTRA-TUMOR POPULATION SHIFTS AND DISCOVERY OF RATIONAL DRUG COMBINATIONS IN HUMAN GLIOBLASTOMA

PURPOSE: Investigation of clonal heterogeneity may be key to understanding mechanisms of therapeutic failure in human cancer. However, little is known on the consequences of therapeutic intervention on the clonal composition of solid tumors. EXPERIMENTAL DESIGN: Here, we used 33 single cell-derived...

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Publicado no:Clin Cancer Res
Main Authors: Reinartz, Roman, Wang, Shanshan, Kebir, Sied, Silver, Daniel J., Wieland, Anja, Zheng, Tong, Küpper, Marius, Rauschenbach, Laurèl, Fimmers, Rolf, Shepherd, Timothy M., Trageser, Daniel, Till, Andreas, Schäfer, Niklas, Glas, Martin, Hillmer, Axel M., Cichon, Sven, Smith, Amy A., Pietsch, Torsten, Liu, Ying, Reynolds, Brent A., Yachnis, Anthony, Pincus, David W., Simon, Matthias, Brüstle, Oliver, Steindler, Dennis A., Scheffler, Björn
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5241221/
https://ncbi.nlm.nih.gov/pubmed/27521447
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-15-2089
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