Substrate Stiffness Controls Osteoblastic and Chondrocytic Differentiation of Mesenchymal Stem Cells without Exogenous Stimuli

Stem cell fate has been linked to the mechanical properties of their underlying substrate, affecting mechanoreceptors and ultimately leading to downstream biological response. Studies have used polymers to mimic the stiffness of extracellular matrix as well as of individual tissues and shown mesench...

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Publicat a:PLoS One
Autors principals: Olivares-Navarrete, Rene, Lee, Erin M., Smith, Kathryn, Hyzy, Sharon L., Doroudi, Maryam, Williams, Joseph K., Gall, Ken, Boyan, Barbara D., Schwartz, Zvi
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2017
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5240960/
https://ncbi.nlm.nih.gov/pubmed/28095466
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0170312
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