Substrate Stiffness Controls Osteoblastic and Chondrocytic Differentiation of Mesenchymal Stem Cells without Exogenous Stimuli

Stem cell fate has been linked to the mechanical properties of their underlying substrate, affecting mechanoreceptors and ultimately leading to downstream biological response. Studies have used polymers to mimic the stiffness of extracellular matrix as well as of individual tissues and shown mesench...

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Pubblicato in:PLoS One
Autori principali: Olivares-Navarrete, Rene, Lee, Erin M., Smith, Kathryn, Hyzy, Sharon L., Doroudi, Maryam, Williams, Joseph K., Gall, Ken, Boyan, Barbara D., Schwartz, Zvi
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2017
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5240960/
https://ncbi.nlm.nih.gov/pubmed/28095466
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0170312
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