Association of Body Mass Index with DNA Methylation and Gene Expression in Blood Cells and Relations to Cardiometabolic Disease: A Mendelian Randomization Approach

BACKGROUND: The link between DNA methylation, obesity, and adiposity-related diseases in the general population remains uncertain. METHODS AND FINDINGS: We conducted an association study of body mass index (BMI) and differential methylation for over 400,000 CpGs assayed by microarray in whole-blood-...

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Xehetasun bibliografikoak
Argitaratua izan da:PLoS Med
Egile Nagusiak: Mendelson, Michael M., Marioni, Riccardo E., Joehanes, Roby, Liu, Chunyu, Hedman, Åsa K., Aslibekyan, Stella, Demerath, Ellen W., Guan, Weihua, Zhi, Degui, Yao, Chen, Huan, Tianxiao, Willinger, Christine, Chen, Brian, Courchesne, Paul, Multhaup, Michael, Irvin, Marguerite R., Cohain, Ariella, Schadt, Eric E., Grove, Megan L., Bressler, Jan, North, Kari, Sundström, Johan, Gustafsson, Stefan, Shah, Sonia, McRae, Allan F., Harris, Sarah E., Gibson, Jude, Redmond, Paul, Corley, Janie, Murphy, Lee, Starr, John M., Kleinbrink, Erica, Lipovich, Leonard, Visscher, Peter M., Wray, Naomi R., Krauss, Ronald M., Fallin, Daniele, Feinberg, Andrew, Absher, Devin M., Fornage, Myriam, Pankow, James S., Lind, Lars, Fox, Caroline, Ingelsson, Erik, Arnett, Donna K., Boerwinkle, Eric, Liang, Liming, Levy, Daniel, Deary, Ian J.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Public Library of Science 2017
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5240936/
https://ncbi.nlm.nih.gov/pubmed/28095459
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pmed.1002215
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