Association of Body Mass Index with DNA Methylation and Gene Expression in Blood Cells and Relations to Cardiometabolic Disease: A Mendelian Randomization Approach

BACKGROUND: The link between DNA methylation, obesity, and adiposity-related diseases in the general population remains uncertain. METHODS AND FINDINGS: We conducted an association study of body mass index (BMI) and differential methylation for over 400,000 CpGs assayed by microarray in whole-blood-...

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Vydáno v:PLoS Med
Hlavní autoři: Mendelson, Michael M., Marioni, Riccardo E., Joehanes, Roby, Liu, Chunyu, Hedman, Åsa K., Aslibekyan, Stella, Demerath, Ellen W., Guan, Weihua, Zhi, Degui, Yao, Chen, Huan, Tianxiao, Willinger, Christine, Chen, Brian, Courchesne, Paul, Multhaup, Michael, Irvin, Marguerite R., Cohain, Ariella, Schadt, Eric E., Grove, Megan L., Bressler, Jan, North, Kari, Sundström, Johan, Gustafsson, Stefan, Shah, Sonia, McRae, Allan F., Harris, Sarah E., Gibson, Jude, Redmond, Paul, Corley, Janie, Murphy, Lee, Starr, John M., Kleinbrink, Erica, Lipovich, Leonard, Visscher, Peter M., Wray, Naomi R., Krauss, Ronald M., Fallin, Daniele, Feinberg, Andrew, Absher, Devin M., Fornage, Myriam, Pankow, James S., Lind, Lars, Fox, Caroline, Ingelsson, Erik, Arnett, Donna K., Boerwinkle, Eric, Liang, Liming, Levy, Daniel, Deary, Ian J.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2017
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5240936/
https://ncbi.nlm.nih.gov/pubmed/28095459
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pmed.1002215
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