Aberrantly expressed LGR4 empowers Wnt signaling in multiple myeloma by hijacking osteoblast-derived R-spondins

The unrestrained growth of tumor cells is generally attributed to mutations in essential growth control genes, but tumor cells are also affected by, or even addicted to, signals from the microenvironment. As therapeutic targets, these extrinsic signals may be equally significant as mutated oncogenes...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: van Andel, Harmen, Ren, Zemin, Koopmans, Iris, Joosten, Sander P. J., Kocemba, Kinga A., de Lau, Wim, Kersten, Marie José, de Bruin, Alexander M., Guikema, Jeroen E. J., Clevers, Hans, Spaargaren, Marcel, Pals, Steven T.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2017
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5240718/
https://ncbi.nlm.nih.gov/pubmed/28028233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1618650114
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