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The R-spondin/Lgr5/Rnf43 module: regulator of Wnt signal strength
Lgr5 was originally discovered as a common Wnt target gene in adult intestinal crypts and colon cancer. It was subsequently identified as an exquisite marker of multiple Wnt-driven adult stem cell types. Lgr5 and its homologs, Lgr4 and Lgr6, constitute the receptors for R-spondins, potent Wnt signal...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Cold Spring Harbor Laboratory Press
2014
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3937510/ https://ncbi.nlm.nih.gov/pubmed/24532711 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.235473.113 |
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