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The R-spondin/Lgr5/Rnf43 module: regulator of Wnt signal strength

Lgr5 was originally discovered as a common Wnt target gene in adult intestinal crypts and colon cancer. It was subsequently identified as an exquisite marker of multiple Wnt-driven adult stem cell types. Lgr5 and its homologs, Lgr4 and Lgr6, constitute the receptors for R-spondins, potent Wnt signal...

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Hlavní autoři: de Lau, Wim, Peng, Weng Chuan, Gros, Piet, Clevers, Hans
Médium: Artigo
Jazyk:Inglês
Vydáno: Cold Spring Harbor Laboratory Press 2014
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3937510/
https://ncbi.nlm.nih.gov/pubmed/24532711
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.235473.113
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