Structures of Wnt-Antagonist ZNRF3 and Its Complex with R-Spondin 1 and Implications for Signaling

Zinc RING finger 3 (ZNRF3) and its homolog RING finger 43 (RNF43) antagonize Wnt signaling in adult stem cells by ubiquitinating Frizzled receptors (FZD), which leads to endocytosis of the Wnt receptor. Conversely, binding of ZNRF3/RNF43 to LGR4-6 – R-spondin blocks Frizzled ubiquitination and enhan...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Peng, Weng Chuan, de Lau, Wim, Madoori, Pramod K., Forneris, Federico, Granneman, Joke C. M., Clevers, Hans, Gros, Piet
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3861454/
https://ncbi.nlm.nih.gov/pubmed/24349440
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0083110
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados