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The R-spondin protein family

The four vertebrate R-spondin proteins are secreted agonists of the canonical Wnt/β-catenin signaling pathway. These proteins are approximately 35 kDa, and are characterized by two amino-terminal furin-like repeats, which are necessary and sufficient for Wnt signal potentiation, and a thrombospondin...

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Detalhes bibliográficos
Main Authors: de Lau, Wim BM, Snel, Berend, Clevers, Hans C
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3439965/
https://ncbi.nlm.nih.gov/pubmed/22439850
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/gb-2012-13-3-242
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