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Adult mammalian stem cells: the role of Wnt, Lgr5 and R-spondins
After its discovery as oncogen and morphogen, studies on Wnt focused initially on its role in animal development. With the finding that the colorectal tumour suppressor gene APC is a negative regulator of the Wnt pathway in (colorectal) cancer, attention gradually shifted to the study of the role of...
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| Auteurs principaux: | , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Nature Publishing Group
2012
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3380219/ https://ncbi.nlm.nih.gov/pubmed/22617424 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2012.149 |
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