Aberrantly expressed LGR4 empowers Wnt signaling in multiple myeloma by hijacking osteoblast-derived R-spondins

The unrestrained growth of tumor cells is generally attributed to mutations in essential growth control genes, but tumor cells are also affected by, or even addicted to, signals from the microenvironment. As therapeutic targets, these extrinsic signals may be equally significant as mutated oncogenes...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: van Andel, Harmen, Ren, Zemin, Koopmans, Iris, Joosten, Sander P. J., Kocemba, Kinga A., de Lau, Wim, Kersten, Marie José, de Bruin, Alexander M., Guikema, Jeroen E. J., Clevers, Hans, Spaargaren, Marcel, Pals, Steven T.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2017
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5240718/
https://ncbi.nlm.nih.gov/pubmed/28028233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1618650114
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados