The TGF-β inhibitory activity of antibody 37E1B5 depends on its H-CDR2 glycan

Excessive transforming growth factor (TGF)-β is associated with pro-fibrotic responses in lung disease, yet it also plays essential roles in tissue homeostasis and autoimmunity. Therefore, selective inhibition of excessive and aberrant integrin-mediated TGF-β activation via targeting the α-v family...

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Detalhes bibliográficos
Publicado no:MAbs
Main Authors: Tsui, Ping, Higazi, Daniel R., Wu, Yanli, Dunmore, Rebecca, Solier, Emilie, Kasali, Toyin, Bond, Nicholas J., Huntington, Catherine, Carruthers, Alan, Hood, John, Borrok, M. Jack, Barnes, Arnita, Rickert, Keith, Phipps, Sandrina, Shirinian, Lena, Zhu, Jie, Bowen, Michael A., Dall'Acqua, William, Murray, Lynne A.
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2016
Assuntos:
Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5240645/
https://ncbi.nlm.nih.gov/pubmed/27834568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2016.1255390
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