Crystal structure of a eukaryotic zinc-dependent histone deacetylase, human HDAC8, complexed with a hydroxamic acid inhibitor

Histone deacetylases (HDACs) are a family of enzymes involved in the regulation of gene expression, DNA repair, and stress response. These processes often are altered in tumors, and HDAC inhibitors have had pronounced antitumor activity with promising results in clinical trials. Here, we report the...

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Detalhes bibliográficos
Main Authors: Vannini, Alessandro, Volpari, Cinzia, Filocamo, Gessica, Casavola, Elena Caroli, Brunetti, Mirko, Renzoni, Debora, Chakravarty, Prasun, Paolini, Chantal, De Francesco, Raffaele, Gallinari, Paola, Steinkühler, Christian, Di Marco, Stefania
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2004
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC524051/
https://ncbi.nlm.nih.gov/pubmed/15477595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0404603101
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