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Substrate binding to histone deacetylases as shown by the crystal structure of the HDAC8–substrate complex
Histone deacetylases (HDACs)—an enzyme family that deacetylates histones and non-histone proteins—are implicated in human diseases such as cancer, and the first-generation of HDAC inhibitors are now in clinical trials. Here, we report the 2.0 Å resolution crystal structure of a catalytically inactiv...
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| Autori principali: | , , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Publishing Group
2007
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1973954/ https://ncbi.nlm.nih.gov/pubmed/17721440 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.embor.7401047 |
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