Substrate binding to histone deacetylases as shown by the crystal structure of the HDAC8–substrate complex

Histone deacetylases (HDACs)—an enzyme family that deacetylates histones and non-histone proteins—are implicated in human diseases such as cancer, and the first-generation of HDAC inhibitors are now in clinical trials. Here, we report the 2.0 Å resolution crystal structure of a catalytically inactiv...

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Bibliographische Detailangaben
Hauptverfasser: Vannini, Alessandro, Volpari, Cinzia, Gallinari, Paola, Jones, Philip, Mattu, Marco, Carfí, Andrea, De Francesco, Raffaele, Steinkühler, Christian, Di Marco, Stefania
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2007
Schlagworte:
Scientific Report
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1973954/
https://ncbi.nlm.nih.gov/pubmed/17721440
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.embor.7401047
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