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Crystal structure of a eukaryotic zinc-dependent histone deacetylase, human HDAC8, complexed with a hydroxamic acid inhibitor

Histone deacetylases (HDACs) are a family of enzymes involved in the regulation of gene expression, DNA repair, and stress response. These processes often are altered in tumors, and HDAC inhibitors have had pronounced antitumor activity with promising results in clinical trials. Here, we report the...

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Bibliografski detalji
Glavni autori: Vannini, Alessandro, Volpari, Cinzia, Filocamo, Gessica, Casavola, Elena Caroli, Brunetti, Mirko, Renzoni, Debora, Chakravarty, Prasun, Paolini, Chantal, De Francesco, Raffaele, Gallinari, Paola, Steinkühler, Christian, Di Marco, Stefania
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2004
Teme:
Biological Sciences
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC524051/
https://ncbi.nlm.nih.gov/pubmed/15477595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0404603101
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