Poly(ADP-ribose) polymerase inhibitors activate the p53 signaling pathway in neural stem/progenitor cells

BACKGROUND: Poly(ADP-ribose) polymerase 1 (PARP-1), which catalyzes poly(ADP-ribosyl)ation of proteins by using NAD(+) as a substrate, plays a key role in several nuclear events, including DNA repair, replication, and transcription. Recently, PARP-1 was reported to participate in the somatic cell re...

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Detalhes bibliográficos
Publicado no:BMC Neurosci
Main Authors: Okuda, Akiko, Kurokawa, Suguru, Takehashi, Masanori, Maeda, Aika, Fukuda, Katsuya, Kubo, Yukari, Nogusa, Hyuma, Takatani-Nakase, Tomoka, Okuda, Shujiro, Ueda, Kunihiro, Tanaka, Seigo
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5240207/
https://ncbi.nlm.nih.gov/pubmed/28095779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12868-016-0333-0
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