Identification of a germ-line mutation in the p53 gene in a patient with an intracranial ependymoma.

We detected a germ-line mutation of the p53 gene in a patient with a malignant ependymoma of the posterior fossa. This mutation, which was found at codon 242, resulted in an amino acid substitution in a highly conserved site of exon 7 of the p53 gene; the same mutation was found in both the germ-lin...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Metzger, A K, Sheffield, V C, Duyk, G, Daneshvar, L, Edwards, M S, Cogen, P H
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1991
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC52396/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1679237/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.88.17.7825
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