A simple p53 functional assay for screening cell lines, blood, and tumors.

Mutations in the p53 gene are implicated in the pathogenesis of half of all human tumors. We have developed a simple functional assay for p53 mutation in which human p53 expressed in Saccharomyces cerevisiae activates transcription of the ADE2 gene. Consequently, yeast colonies containing wild-type...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Flaman, J M, Frebourg, T, Moreau, V, Charbonnier, F, Martin, C, Chappuis, P, Sappino, A P, Limacher, I M, Bron, L, Benhattar, J
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1995
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC42082/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7732013/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.9.3963
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