A simple p53 functional assay for screening cell lines, blood, and tumors.

Mutations in the p53 gene are implicated in the pathogenesis of half of all human tumors. We have developed a simple functional assay for p53 mutation in which human p53 expressed in Saccharomyces cerevisiae activates transcription of the ADE2 gene. Consequently, yeast colonies containing wild-type...

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Detalhes bibliográficos
Main Authors: Flaman, J M, Frebourg, T, Moreau, V, Charbonnier, F, Martin, C, Chappuis, P, Sappino, A P, Limacher, I M, Bron, L, Benhattar, J
Formato: Artigo
Idioma:Inglês
Publicado em: 1995
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC42082/
https://ncbi.nlm.nih.gov/pubmed/7732013
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