Partial loss of interleukin 2 receptor gamma function in pigs provides mechanistic insights for the study of human immunodeficiency syndrome

In this study, we described the phenotype of monoallelic interleukin 2 receptor gamma knockout (mIL2RG(+/Δ69-368) KO) pigs. Approximately 80% of mIL2RG(+/Δ69-368) KO pigs (8/10) were athymic, whereas 20% (2/10) presented a rudimentary thymus. The body weight of IL2RG(+/Δ69-368)KO pigs developed norm...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Choi, Yun-Jung, Lee, Kiho, Park, Woo-Jin, Kwon, Deug-Nam, Park, Chankyu, Do, Jeong Tae, Song, Hyuk, Cho, Seong-Keun, Park, Kwang-Wook, Brown, Alana N., Samuel, Melissa S., Murphy, Clifton N., Prather, Randall S., Kim, Jin-Hoi
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper: Pathology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5239447/
https://ncbi.nlm.nih.gov/pubmed/27463006
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.10812
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