Engraftment of human iPS cells and allogeneic porcine cells into pigs with inactivated RAG2 and accompanying severe combined immunodeficiency

Pigs with severe combined immunodeficiency (SCID) may provide useful models for regenerative medicine, xenotransplantation, and tumor development and will aid in developing therapies for human SCID patients. Using a reporter-guided transcription activator-like effector nuclease (TALEN) system, we ge...

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Detalhes bibliográficos
Main Authors: Lee, Kiho, Kwon, Deug-Nam, Ezashi, Toshihiko, Choi, Yun-Jung, Park, Chankyu, Ericsson, Aaron C., Brown, Alana N., Samuel, Melissa S., Park, Kwang-Wook, Walters, Eric M., Kim, Dae Young, Kim, Jae-Hwan, Franklin, Craig L., Murphy, Clifton N., Roberts, R. Michael, Prather, Randall S., Kim, Jin-Hoi
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4034252/
https://ncbi.nlm.nih.gov/pubmed/24799706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1406376111
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