Recurrent, truncating SOX9 mutations are associated with SOX9 overexpression, KRAS mutation, and TP53 wild type status in colorectal carcinoma

PURPOSE: The extent to which the developmental transcription factor SOX9 functions as an oncogene or tumor suppressor in colorectal carcinoma (CRC) is debatable. We aimed to clarify the effect of SOX9 mutations on SOX9 protein expression and their association with known molecular subtypes and clinic...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Javier, Breanna M., Yaeger, Rona, Wang, Lu, Sanchez-Vega, Francisco, Zehir, Ahmet, Middha, Sumit, Sadowska, Justyna, Vakiani, Efsevia, Shia, Jinru, Klimstra, David, Ladanyi, Marc, Iacobuzio-Donahue, Christine A., Hechtman, Jaclyn F.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper: Pathology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5239443/
https://ncbi.nlm.nih.gov/pubmed/27248473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.9682
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