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The role of tetrahydrobiopterin in inflammation and cardiovascular disease
The cofactor tetrahydrobiopterin (BH4) is required for nitric oxide (NO) production by all nitric oxide synthase (NOS) enzymes and is a key regulator of cellular redox signalling. When BH4 levels become limiting NOS enzymes become ‘uncoupled’ and produce superoxide rather than NO. Endothelial cell B...
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| Publicado en: | Thromb Haemost |
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| Autores principales: | , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2012
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5238931/ https://ncbi.nlm.nih.gov/pubmed/23052970 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1160/TH12-06-0424 |
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