Characterization of a programmed alteration in an 18S ribosomal gene that accompanies the experimental induction of drug resistance in Schistosoma mansoni.

Stable resistance to the anthelmintic hycanthone can be produced in the human blood fluke Schistosoma mansoni by exposing immature parasites in mice to the drug. Within a single generation, genomic rearrangements, detected as rRNA-encoding DNA restriction fragment length polymorphisms (RFLPs), accom...

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-д хэвлэсэн:	Proc Natl Acad Sci U S A
Үндсэн зохиолчид:	Brindley, P J, Heath, S, Waters, A P, McCutchan, T F, Sher, A
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	National Academy of Sciences 1991
Нөхцлүүд:	Research Article
Онлайн хандалт:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC52381/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1679236/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.88.17.7754
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