Characterization of a programmed alteration in an 18S ribosomal gene that accompanies the experimental induction of drug resistance in Schistosoma mansoni.

Stable resistance to the anthelmintic hycanthone can be produced in the human blood fluke Schistosoma mansoni by exposing immature parasites in mice to the drug. Within a single generation, genomic rearrangements, detected as rRNA-encoding DNA restriction fragment length polymorphisms (RFLPs), accom...

Ausführliche Beschreibung

Bibliografische Detailangaben

Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Brindley, P J, Heath, S, Waters, A P, McCutchan, T F, Sher, A
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 1991
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC52381/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1679236/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.88.17.7754
Tags:	Tag hinzufügen Keine Tags, Fügen Sie das erste Tag hinzu!