Characterization of a programmed alteration in an 18S ribosomal gene that accompanies the experimental induction of drug resistance in Schistosoma mansoni.

Stable resistance to the anthelmintic hycanthone can be produced in the human blood fluke Schistosoma mansoni by exposing immature parasites in mice to the drug. Within a single generation, genomic rearrangements, detected as rRNA-encoding DNA restriction fragment length polymorphisms (RFLPs), accom...

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Bibliografische gegevens

Gepubliceerd in:	Proc Natl Acad Sci U S A
Hoofdauteurs:	Brindley, P J, Heath, S, Waters, A P, McCutchan, T F, Sher, A
Formaat:	Artigo
Taal:	Inglês
Gepubliceerd in:	National Academy of Sciences 1991
Onderwerpen:	Research Article
Online toegang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC52381/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1679236/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.88.17.7754
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