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Mechanisms of mutagenesis: DNA replication in the presence of DNA damage

Environmental mutagens cause DNA damage that disturbs replication and produces mutations, leading to cancer and other diseases. We discuss mechanisms of mutagenesis resulting from DNA damage, from the level of DNA replication by a single polymerase to the complex DNA replisome of some typical model...

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Detalhes bibliográficos
Publicado no:Mutat Res Rev Mutat Res
Main Authors: Liu, Binyan, Xue, Qizhen, Tang, Yong, Cao, Jia, Guengerich, F. Peter, Zhang, Huidong
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5237373/
https://ncbi.nlm.nih.gov/pubmed/27234563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mrrev.2016.03.006
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