Reduced beta 2-microglobulin mRNA levels in transgenic mice expressing a designed hammerhead ribozyme.

We have generated three artificial hammerhead ribozymes, denoted 'Rz-b', 'Rz-c' and 'Rz-d', with different specificities for exon II of the mouse beta-2-microglobulin (beta 2M) mRNA. In this study we tested for ribozyme mediated reduction of beta 2M mRNA in a cell line and in transgenic mice. Transf...

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Detalhes bibliográficos

Publicado no:	Nucleic Acids Res
Principais autores:	Larsson, S, Hotchkiss, G, Andäng, M, Nyholm, T, Inzunza, J, Jansson, I, Ahrlund-Richter, L
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Oxford University Press 1994
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC523680/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8036151/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/22.12.2242
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