Reduced beta 2-microglobulin mRNA levels in transgenic mice expressing a designed hammerhead ribozyme.

We have generated three artificial hammerhead ribozymes, denoted 'Rz-b', 'Rz-c' and 'Rz-d', with different specificities for exon II of the mouse beta-2-microglobulin (beta 2M) mRNA. In this study we tested for ribozyme mediated reduction of beta 2M mRNA in a cell line...

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Main Authors: Larsson, S, Hotchkiss, G, Andäng, M, Nyholm, T, Inzunza, J, Jansson, I, Ahrlund-Richter, L
Format: Artigo
Jezik:Inglês
Izdano: 1994
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC523680/
https://ncbi.nlm.nih.gov/pubmed/8036151
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