Localization of 1-deoxysphingolipids to mitochondria induces mitochondrial dysfunction

1-Deoxysphingolipids (deoxySLs) are atypical sphingolipids that are elevated in the plasma of patients with type 2 diabetes and hereditary sensory and autonomic neuropathy type 1 (HSAN1). Clinically, diabetic neuropathy and HSAN1 are very similar, suggesting the involvement of deoxySLs in the pathol...

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Bibliografiska uppgifter
I publikationen:J Lipid Res
Huvudupphovsmän: Alecu, Irina, Tedeschi, Andrea, Behler, Natascha, Wunderling, Klaus, Lamberz, Christian, Lauterbach, Mario A. R., Gaebler, Anne, Ernst, Daniela, Van Veldhoven, Paul P., Al-Amoudi, Ashraf, Latz, Eicke, Othman, Alaa, Kuerschner, Lars, Hornemann, Thorsten, Bradke, Frank, Thiele, Christoph, Penno, Anke
Materialtyp: Artigo
Språk:Inglês
Publicerad: The American Society for Biochemistry and Molecular Biology 2017
Ämnen:
Research Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5234710/
https://ncbi.nlm.nih.gov/pubmed/27881717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M068676
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