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Cytotoxic 1-deoxysphingolipids are metabolized by a cytochrome P450-dependent pathway
The 1-deoxysphingolipids (1-deoxySLs) are atypical sphingolipids (SLs) that are formed when serine palmitoyltransferase condenses palmitoyl-CoA with alanine instead of serine during SL synthesis. The 1-deoxySLs are toxic to neurons and pancreatic β-cells. Pathologically elevated 1-deoxySLs cause the...
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| Publicado no: | J Lipid Res |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The American Society for Biochemistry and Molecular Biology
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5234722/ https://ncbi.nlm.nih.gov/pubmed/27872144 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M072421 |
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