Neurotoxic 1-deoxysphingolipids and paclitaxel-induced peripheral neuropathy

Peripheral neuropathy is a major dose-limiting side effect of paclitaxel and cisplatin chemotherapy. In the current study, we tested the involvement of a novel class of neurotoxic sphingolipids, the 1-deoxysphingolipids. 1-Deoxysphingolipids are produced when the enzyme serine palmitoyltransferase u...

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Detalhes bibliográficos
Publicado no:FASEB J
Main Authors: Kramer, Rita, Bielawski, Jacek, Kistner-Griffin, Emily, Othman, Alaa, Alecu, Irina, Ernst, Daniela, Kornhauser, Drew, Hornemann, Thorsten, Spassieva, Stefka
Formato: Artigo
Idioma:Inglês
Publicado em: Federation of American Societies for Experimental Biology 2015
Assuntos:
Research Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4608911/
https://ncbi.nlm.nih.gov/pubmed/26198449
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.15-272567
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