Role of a transductional-transcriptional processor complex involving MyD88 and IRF-7 in Toll-like receptor signaling

Toll-like receptor (TLR) activation is central to immunity, wherein the activation of the TLR9 subfamily members TLR9 and TLR7 results in the robust induction of type I IFNs (IFN-α/β) by means of the MyD88 adaptor protein. However, it remains unknown how the TLR signal “input” can be processed throu...

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Bibliographic Details
Main Authors: Honda, Kenya, Yanai, Hideyuki, Mizutani, Tatsuaki, Negishi, Hideo, Shimada, Naoya, Suzuki, Nobutaka, Ohba, Yusuke, Takaoka, Akinori, Yeh, Wen-Chen, Taniguchi, Tadatsugu
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2004
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC523464/
https://ncbi.nlm.nih.gov/pubmed/15492225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0406933101
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