Bacteriolytic therapy can generate a potent immune response against experimental tumors

When spores of the anaerobic bacterium Clostridium novyi-NT are systemically injected into animals, they germinate exclusively within the hypoxic regions of cancers. The germinated bacteria destroy adjacent tumor cells but spare a rim of well oxygenated tumor cells that subsequently expand. Surprisi...

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Detalhes bibliográficos
Main Authors: Agrawal, Nishant, Bettegowda, Chetan, Cheong, Ian, Geschwind, Jean-Francois, Drake, Charles G., Hipkiss, Edward L., Tatsumi, Mitsuaki, Dang, Long H., Diaz, Luis A., Pomper, Martin, Abusedera, Mohammad, Wahl, Richard L., Kinzler, Kenneth W., Zhou, Shibin, Huso, David L., Vogelstein, Bert
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2004
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC523456/
https://ncbi.nlm.nih.gov/pubmed/15471990
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0406242101
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