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FVIII-specific human chimeric antigen receptor T-regulatory cells suppress T- and B-cell responses to FVIII

Replacement therapy with factor VIII (FVIII) is used in patients with hemophilia A for treatment of bleeding episodes or for prophylaxis. A common and serious problem with this therapy is the patient’s immune response to FVIII, because of a lack of tolerance, leading to the formation of inhibitory a...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Blood
Prif Awduron: Yoon, Jeongheon, Schmidt, Anja, Zhang, Ai-Hong, Königs, Christoph, Kim, Yong Chan, Scott, David W.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society of Hematology 2017
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5234219/
https://ncbi.nlm.nih.gov/pubmed/28064157
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2016-07-727834
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