Enhanced Mucosal Defense and Reduced Tumor Burden in Mice with the Compromised Negative Regulator IRAK-M

Aberrant inflammation is a hallmark of inflammatory bowel disease (IBD) and colorectal cancer. IRAK-M is a critical negative regulator of TLR signaling and overzealous inflammation. Here we utilize data from human studies and Irak-m(−/−) mice to elucidate the role of IRAK-M in the modulation of gast...

Description complète

Enregistré dans:
Détails bibliographiques
Publié dans:EBioMedicine
Auteurs principaux: Rothschild, Daniel E., Zhang, Yao, Diao, Na, Lee, Christina K., Chen, Keqiang, Caswell, Clayton C., Slade, Daniel J., Helm, Richard F., LeRoith, Tanya, Li, Liwu, Allen, Irving C.
Format: Artigo
Langue:Inglês
Publié: Elsevier 2016
Sujets:
Research Paper
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5233813/
https://ncbi.nlm.nih.gov/pubmed/27939424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2016.11.039
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires