Enhanced Mucosal Defense and Reduced Tumor Burden in Mice with the Compromised Negative Regulator IRAK-M

Aberrant inflammation is a hallmark of inflammatory bowel disease (IBD) and colorectal cancer. IRAK-M is a critical negative regulator of TLR signaling and overzealous inflammation. Here we utilize data from human studies and Irak-m(−/−) mice to elucidate the role of IRAK-M in the modulation of gast...

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Detalhes bibliográficos
Publicado no:EBioMedicine
Main Authors: Rothschild, Daniel E., Zhang, Yao, Diao, Na, Lee, Christina K., Chen, Keqiang, Caswell, Clayton C., Slade, Daniel J., Helm, Richard F., LeRoith, Tanya, Li, Liwu, Allen, Irving C.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5233813/
https://ncbi.nlm.nih.gov/pubmed/27939424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2016.11.039
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