RAD51 Is a Selective DNA Repair Target to Radiosensitize Glioma Stem Cells

Patients with glioblastoma die from local relapse despite surgery and high-dose radiotherapy. Resistance to radiotherapy is thought to be due to efficient DNA double-strand break (DSB) repair in stem-like cells able to survive DNA damage and repopulate the tumor. We used clinical samples and patient...

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Udgivet i:Stem Cell Reports
Main Authors: King, Harry O., Brend, Tim, Payne, Helen L., Wright, Alexander, Ward, Thomas A., Patel, Karan, Egnuni, Teklu, Stead, Lucy F., Patel, Anjana, Wurdak, Heiko, Short, Susan C.
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5233453/
https://ncbi.nlm.nih.gov/pubmed/28076755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2016.12.005
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